Using the random forest method to detect a response shift in the quality of life of multiple sclerosis patients: a cohort study
Identifieur interne : 002104 ( Main/Exploration ); précédent : 002103; suivant : 002105Using the random forest method to detect a response shift in the quality of life of multiple sclerosis patients: a cohort study
Auteurs : Mohamed Boucekine [France] ; Anderson Loundou [France] ; Karine Baumstarck [France] ; Patricia Minaya-Flores [France] ; Jean Pelletier [France] ; Badih Ghattas [France] ; Pascal Auquier [France]Source :
- BMC Medical Research Methodology [ 1471-2288 ] ; 2013.
Abstract
Multiple sclerosis (MS), a common neurodegenerative disease, has well-described associations with quality of life (QoL) impairment. QoL changes found in longitudinal studies are difficult to interpret due to the potential response shift (RS) corresponding to respondents’ changing standards, values, and conceptualization of QoL. This study proposes to test the capacity of Random Forest (RF) for detecting RS reprioritization as the relative importance of QoL domains’ changes over time.
This was a longitudinal observational study. The main inclusion criteria were patients 18 years old or more with relapsing-remitting multiple sclerosis. Every 6 months up to month 24, QoL was recorded using generic and MS-specific questionnaires (MusiQoL and SF-36). At 24 months, individuals were divided into two ‘disability change’ groups: worsened and not-worsened patients. The RF method was performed based on Breiman’s description. Analyses were performed to determine which QoL scores of SF-36 predicted the MusiQoL index. The average variable importance (AVI) was estimated.
A total of 417 (79.6%) patients were defined as not-worsened and 107 (20.4%) as worsened. A clear RS was identified in worsened patients. While the mental score AVI was almost one third higher than the physical score AVI at 12 months, it was 1.5 times lower at 24 months.
This work confirms that the RF method offers a useful statistical approach for RS detection. How to integrate the RS in the interpretation of QoL scores remains a challenge for future research.
ClinicalTrials.gov identifier:
Url:
DOI: 10.1186/1471-2288-13-20
PubMed: 23414459
PubMed Central: 3626785
Affiliations:
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type="wicri:Area/Main/Exploration">002104</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Using the random forest method to detect a response shift in the quality of life of multiple sclerosis patients: a cohort study</title><author><name sortKey="Boucekine, Mohamed" sort="Boucekine, Mohamed" uniqKey="Boucekine M" first="Mohamed" last="Boucekine">Mohamed Boucekine</name><affiliation wicri:level="4"><nlm:aff id="I1">EA3279, Self-perceived Health Assessment Research Unit, School of Medicine, Université de la Méditerranée, 27 bd Jean Moulin, Marseille cedex 05, F-13385, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA3279, Self-perceived Health Assessment Research Unit, School of Medicine, Université de la Méditerranée, 27 bd Jean Moulin, Marseille cedex 05, F-13385</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université de la Méditerranée</orgName></affiliation></author><author><name sortKey="Loundou, Anderson" sort="Loundou, Anderson" uniqKey="Loundou A" first="Anderson" last="Loundou">Anderson Loundou</name><affiliation wicri:level="4"><nlm:aff id="I1">EA3279, Self-perceived Health Assessment Research Unit, School of Medicine, Université de la Méditerranée, 27 bd Jean Moulin, Marseille cedex 05, F-13385, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA3279, Self-perceived Health Assessment Research Unit, School of Medicine, Université de la Méditerranée, 27 bd Jean Moulin, Marseille cedex 05, F-13385</wicri:regionArea><wicri:noRegion>13385</wicri:noRegion><orgName type="university">Université de la Méditerranée</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Baumstarck, Karine" sort="Baumstarck, Karine" uniqKey="Baumstarck K" first="Karine" last="Baumstarck">Karine Baumstarck</name><affiliation wicri:level="4"><nlm:aff id="I1">EA3279, Self-perceived Health Assessment Research Unit, School of Medicine, Université de la Méditerranée, 27 bd Jean Moulin, Marseille cedex 05, F-13385, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA3279, Self-perceived Health Assessment Research Unit, School of Medicine, Université de la Méditerranée, 27 bd Jean Moulin, Marseille cedex 05, F-13385</wicri:regionArea><wicri:noRegion>13385</wicri:noRegion><orgName type="university">Université de la Méditerranée</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Minaya Flores, Patricia" sort="Minaya Flores, Patricia" uniqKey="Minaya Flores P" first="Patricia" last="Minaya-Flores">Patricia Minaya-Flores</name><affiliation wicri:level="4"><nlm:aff id="I1">EA3279, Self-perceived Health Assessment Research Unit, School of Medicine, Université de la Méditerranée, 27 bd Jean Moulin, Marseille cedex 05, F-13385, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA3279, Self-perceived Health Assessment Research Unit, School of Medicine, Université de la Méditerranée, 27 bd Jean Moulin, Marseille cedex 05, F-13385</wicri:regionArea><wicri:noRegion>13385</wicri:noRegion><orgName type="university">Université de la Méditerranée</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author><author><name sortKey="Pelletier, Jean" sort="Pelletier, Jean" uniqKey="Pelletier J" first="Jean" last="Pelletier">Jean Pelletier</name><affiliation wicri:level="3"><nlm:aff id="I2">Departments of Neurology and CRMBM CNRS6612, Timone University Hospital, APHM, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Departments of Neurology and CRMBM CNRS6612, Timone University Hospital, APHM, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Ghattas, Badih" sort="Ghattas, Badih" uniqKey="Ghattas B" first="Badih" last="Ghattas">Badih Ghattas</name><affiliation wicri:level="3"><nlm:aff id="I3">Department of Mathematics, Faculté des Sciences de Luminy, Aix-Marseille University, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Mathematics, Faculté des Sciences de Luminy, Aix-Marseille University, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Auquier, Pascal" sort="Auquier, Pascal" uniqKey="Auquier P" first="Pascal" last="Auquier">Pascal Auquier</name><affiliation wicri:level="4"><nlm:aff id="I1">EA3279, Self-perceived Health Assessment Research Unit, School of Medicine, Université de la Méditerranée, 27 bd Jean Moulin, Marseille cedex 05, F-13385, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA3279, Self-perceived Health Assessment Research Unit, School of Medicine, Université de la Méditerranée, 27 bd Jean Moulin, Marseille cedex 05, F-13385</wicri:regionArea><wicri:noRegion>13385</wicri:noRegion><orgName type="university">Université de la Méditerranée</orgName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName></affiliation></author></analytic><series><title level="j">BMC Medical Research Methodology</title><idno type="eISSN">1471-2288</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Multiple sclerosis (MS), a common neurodegenerative disease, has well-described associations with quality of life (QoL) impairment. QoL changes found in longitudinal studies are difficult to interpret due to the potential response shift (RS) corresponding to respondents’ changing standards, values, and conceptualization of QoL. This study proposes to test the capacity of Random Forest (RF) for detecting RS reprioritization as the relative importance of QoL domains’ changes over time.</p></sec><sec><title>Methods</title><p>This was a longitudinal observational study. The main inclusion criteria were patients 18 years old or more with relapsing-remitting multiple sclerosis. Every 6 months up to month 24, QoL was recorded using generic and MS-specific questionnaires (MusiQoL and SF-36). At 24 months, individuals were divided into two ‘disability change’ groups: worsened and not-worsened patients. The RF method was performed based on Breiman’s description. Analyses were performed to determine which QoL scores of SF-36 predicted the MusiQoL index. The average variable importance (AVI) was estimated.</p></sec><sec><title>Results</title><p>A total of 417 (79.6%) patients were defined as not-worsened and 107 (20.4%) as worsened. A clear RS was identified in worsened patients. While the mental score AVI was almost one third higher than the physical score AVI at 12 months, it was 1.5 times lower at 24 months.</p></sec><sec><title>Conclusion</title><p>This work confirms that the RF method offers a useful statistical approach for RS detection. How to integrate the RS in the interpretation of QoL scores remains a challenge for future research.</p></sec><sec><title>Trial registration</title><p>ClinicalTrials.gov identifier:
<ext-link ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov/ct2/show/NCT00702065?term=multiple+sclerosis+musiqol%rank=1">NCT00702065</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mitchell, Aj" uniqKey="Mitchell A">AJ Mitchell</name></author><author><name sortKey="Benito Leon, J" uniqKey="Benito Leon J">J Benito-Leon</name></author><author><name sortKey="Gonzalez, Jm" uniqKey="Gonzalez J">JM Gonzalez</name></author><author><name sortKey="Rivera Navarro, J" uniqKey="Rivera Navarro J">J Rivera-Navarro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Solari, A" uniqKey="Solari A">A Solari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Dm" uniqKey="Miller D">DM Miller</name></author><author><name sortKey="Allen, R" uniqKey="Allen R">R Allen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudick, Ra" uniqKey="Rudick R">RA Rudick</name></author><author><name sortKey="Miller, Dm" uniqKey="Miller D">DM Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sprangers, Ma" uniqKey="Sprangers M">MA Sprangers</name></author><author><name sortKey="Schwartz, Ce" uniqKey="Schwartz C">CE Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, Ce" uniqKey="Schwartz C">CE Schwartz</name></author><author><name sortKey="Sprangers, Ma" uniqKey="Sprangers M">MA Sprangers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="King Kallimanis, Bl" uniqKey="King Kallimanis B">BL King-Kallimanis</name></author><author><name sortKey="Oort, Fj" uniqKey="Oort F">FJ Oort</name></author><author><name sortKey="Nolte, S" uniqKey="Nolte S">S Nolte</name></author><author><name sortKey="Schwartz, Ce" uniqKey="Schwartz C">CE Schwartz</name></author><author><name sortKey="Sprangers, Ma" uniqKey="Sprangers M">MA Sprangers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmed, S" uniqKey="Ahmed S">S Ahmed</name></author><author><name sortKey="Mayo, N" uniqKey="Mayo N">N Mayo</name></author><author><name sortKey="Scott, S" uniqKey="Scott S">S Scott</name></author><author><name sortKey="Kuspinar, A" uniqKey="Kuspinar A">A Kuspinar</name></author><author><name sortKey="Schwartz, C" uniqKey="Schwartz C">C Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Schwartz, Ce" uniqKey="Schwartz C">CE Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, Ce" uniqKey="Schwartz C">CE Schwartz</name></author><author><name sortKey="Sprangers, Ma" uniqKey="Sprangers M">MA Sprangers</name></author><author><name sortKey="Oort, F" uniqKey="Oort F">F Oort</name></author><author><name sortKey="Ahmed, S" uniqKey="Ahmed S">S Ahmed</name></author><author><name sortKey="Bode, R" uniqKey="Bode R">R Bode</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Vollmer, T" uniqKey="Vollmer T">T Vollmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breiman, L" uniqKey="Breiman L">L Breiman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breiman, L" uniqKey="Breiman L">L Breiman</name></author><author><name sortKey="Cutler, A" uniqKey="Cutler A">A Cutler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verikas, A" uniqKey="Verikas A">A Verikas</name></author><author><name sortKey="Gelzinis, A" uniqKey="Gelzinis A">A Gelzinis</name></author><author><name sortKey="Bacauskiene, M" uniqKey="Bacauskiene M">M Bacauskiene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Touw, Wg" uniqKey="Touw W">WG Touw</name></author><author><name sortKey="Bayjanov, Jr" uniqKey="Bayjanov J">JR Bayjanov</name></author><author><name sortKey="Overmars, L" uniqKey="Overmars L">L Overmars</name></author><author><name sortKey="Backus, L" uniqKey="Backus L">L Backus</name></author><author><name sortKey="Boekhorst, J" uniqKey="Boekhorst J">J Boekhorst</name></author><author><name sortKey="Wels, M" uniqKey="Wels M">M Wels</name></author><author><name sortKey="Van Hijum, Sa" uniqKey="Van Hijum S">SA van Hijum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Ishwaran, H" uniqKey="Ishwaran H">H Ishwaran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldstein, Ba" uniqKey="Goldstein B">BA Goldstein</name></author><author><name sortKey="Polley, Ec" uniqKey="Polley E">EC Polley</name></author><author><name sortKey="Briggs, Fbs" uniqKey="Briggs F">FBS Briggs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flachenecker, P" uniqKey="Flachenecker P">P Flachenecker</name></author><author><name sortKey="Baumstarck Barrau, K" uniqKey="Baumstarck Barrau K">K Baumstarck-Barrau</name></author><author><name sortKey="Butzkueven, H" uniqKey="Butzkueven H">H Butzkueven</name></author><author><name sortKey="Fernandez, O" uniqKey="Fernandez O">O Fernández</name></author><author><name sortKey="Idiman, E" uniqKey="Idiman E">E Idiman</name></author><author><name sortKey="Pelletier, J" uniqKey="Pelletier J">J Pelletier</name></author><author><name sortKey="Stecchi, S" uniqKey="Stecchi S">S Stecchi</name></author><author><name sortKey="Verdun Di Cantogno, E" uniqKey="Verdun Di Cantogno E">E Verdun di Cantogno</name></author><author><name sortKey="Milner, A" uniqKey="Milner A">A Milner</name></author><author><name sortKey="Auquier, P" uniqKey="Auquier P">P Auquier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcdonald, Wi" uniqKey="Mcdonald W">WI McDonald</name></author><author><name sortKey="Compston, A" uniqKey="Compston A">A Compston</name></author><author><name sortKey="Edan, G" uniqKey="Edan G">G Edan</name></author><author><name sortKey="Goodkin, D" uniqKey="Goodkin D">D Goodkin</name></author><author><name sortKey="Hartung, Hp" uniqKey="Hartung H">HP Hartung</name></author><author><name sortKey="Lublin, Fd" uniqKey="Lublin F">FD Lublin</name></author><author><name sortKey="Mcfarland, Hf" uniqKey="Mcfarland H">HF McFarland</name></author><author><name sortKey="Paty, Dw" uniqKey="Paty D">DW Paty</name></author><author><name sortKey="Polman, Ch" uniqKey="Polman C">CH Polman</name></author><author><name sortKey="Reingold, Sc" uniqKey="Reingold S">SC Reingold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Polman, Ch" uniqKey="Polman C">CH Polman</name></author><author><name sortKey="Wolinsky, Js" uniqKey="Wolinsky J">JS Wolinsky</name></author><author><name sortKey="Reingold, Sc" uniqKey="Reingold S">SC Reingold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kurtzke, Jf" uniqKey="Kurtzke J">JF Kurtzke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simeoni, M" uniqKey="Simeoni M">M Simeoni</name></author><author><name sortKey="Auquier, P" uniqKey="Auquier P">P Auquier</name></author><author><name sortKey="Fernandez, O" uniqKey="Fernandez O">O Fernandez</name></author><author><name sortKey="Flachenecker, P" uniqKey="Flachenecker P">P Flachenecker</name></author><author><name sortKey="Stecchi, S" uniqKey="Stecchi S">S Stecchi</name></author><author><name sortKey="Constantinescu, C" uniqKey="Constantinescu C">C Constantinescu</name></author><author><name sortKey="Idiman, E" uniqKey="Idiman E">E Idiman</name></author><author><name sortKey="Boyko, A" uniqKey="Boyko A">A Boyko</name></author><author><name sortKey="Beiske, A" uniqKey="Beiske A">A Beiske</name></author><author><name sortKey="Vollmer, T" uniqKey="Vollmer T">T Vollmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ware, Je" uniqKey="Ware J">JE Ware</name></author><author><name sortKey="Sherbourne, Cd" uniqKey="Sherbourne C">CD Sherbourne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amato, Mp" uniqKey="Amato M">MP Amato</name></author><author><name sortKey="Grimaud, J" uniqKey="Grimaud J">J Grimaud</name></author><author><name sortKey="Achiti, I" uniqKey="Achiti I">I Achiti</name></author><author><name sortKey="Bartolozzi, Ml" uniqKey="Bartolozzi M">ML Bartolozzi</name></author><author><name sortKey="Adeleine, P" uniqKey="Adeleine P">P Adeleine</name></author><author><name sortKey="Hartung, Hp" uniqKey="Hartung H">HP Hartung</name></author><author><name sortKey="Kappos, L" uniqKey="Kappos L">L Kappos</name></author><author><name sortKey="Thompson, A" uniqKey="Thompson A">A Thompson</name></author><author><name sortKey="Trojano, M" uniqKey="Trojano M">M Trojano</name></author><author><name sortKey="Vukusic, S" uniqKey="Vukusic S">S Vukusic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goodkin, De" uniqKey="Goodkin D">DE Goodkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breiman, L" uniqKey="Breiman L">L Breiman</name></author><author><name sortKey="Friedman, Jh" uniqKey="Friedman J">JH Friedman</name></author><author><name sortKey="Olshen, Ra" uniqKey="Olshen R">RA Olshen</name></author><author><name sortKey="Stone, Cj" uniqKey="Stone C">CJ Stone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dempster, M" uniqKey="Dempster M">M Dempster</name></author><author><name sortKey="Carney, R" uniqKey="Carney R">R Carney</name></author><author><name sortKey="Mcclements, R" uniqKey="Mcclements R">R McClements</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ring, L" uniqKey="Ring L">L Ring</name></author><author><name sortKey="Hofer, S" uniqKey="Hofer S">S Hofer</name></author><author><name sortKey="Heuston, F" uniqKey="Heuston F">F Heuston</name></author><author><name sortKey="Harris, D" uniqKey="Harris D">D Harris</name></author><author><name sortKey="O Boyle, Ca" uniqKey="O Boyle C">CA O'Boyle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandez, O" uniqKey="Fernandez O">O Fernandez</name></author><author><name sortKey="Baumstarck Barrau, K" uniqKey="Baumstarck Barrau K">K Baumstarck-Barrau</name></author><author><name sortKey="Simeoni, Mc" uniqKey="Simeoni M">MC Simeoni</name></author><author><name sortKey="Auquier, P" uniqKey="Auquier P">P Auquier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Norman, G" uniqKey="Norman G">G Norman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oort, Fj" uniqKey="Oort F">FJ Oort</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oort, Fj" uniqKey="Oort F">FJ Oort</name></author><author><name sortKey="Visser, Mr" uniqKey="Visser M">MR Visser</name></author><author><name sortKey="Sprangers, Ma" uniqKey="Sprangers M">MA Sprangers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Rapkin, B" uniqKey="Rapkin B">B Rapkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mayo, Ne" uniqKey="Mayo N">NE Mayo</name></author><author><name sortKey="Scott, Sc" uniqKey="Scott S">SC Scott</name></author><author><name sortKey="Dendukuri, N" uniqKey="Dendukuri N">N Dendukuri</name></author><author><name sortKey="Ahmed, S" uniqKey="Ahmed S">S Ahmed</name></author><author><name sortKey="Wood Dauphinee, S" uniqKey="Wood Dauphinee S">S Wood-Dauphinee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lunetta, Kl" uniqKey="Lunetta K">KL Lunetta</name></author><author><name sortKey="Hayward, Lb" uniqKey="Hayward L">LB Hayward</name></author><author><name sortKey="Segal, J" uniqKey="Segal J">J Segal</name></author><author><name sortKey="Van Eerdewegh, P" uniqKey="Van Eerdewegh P">P Van Eerdewegh</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Liaw, A" uniqKey="Liaw A">A Liaw</name></author><author><name sortKey="Wiener, M" uniqKey="Wiener M">M Wiener</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boyer, L" uniqKey="Boyer L">L Boyer</name></author><author><name sortKey="Auquier, P" uniqKey="Auquier P">P Auquier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Awad, Ag" uniqKey="Awad A">AG Awad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, Ce" uniqKey="Schwartz C">CE Schwartz</name></author><author><name sortKey="Rapkin, Bd" uniqKey="Rapkin B">BD Rapkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rapkin, Bd" uniqKey="Rapkin B">BD Rapkin</name></author><author><name sortKey="Schwartz, Ce" uniqKey="Schwartz C">CE Schwartz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement><orgName><li>Université de la Méditerranée</li></orgName></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Boucekine, Mohamed" sort="Boucekine, Mohamed" uniqKey="Boucekine M" first="Mohamed" last="Boucekine">Mohamed Boucekine</name></region><name sortKey="Auquier, Pascal" sort="Auquier, Pascal" uniqKey="Auquier P" first="Pascal" last="Auquier">Pascal Auquier</name><name sortKey="Baumstarck, Karine" sort="Baumstarck, Karine" uniqKey="Baumstarck K" first="Karine" last="Baumstarck">Karine Baumstarck</name><name sortKey="Ghattas, Badih" sort="Ghattas, Badih" uniqKey="Ghattas B" first="Badih" last="Ghattas">Badih Ghattas</name><name sortKey="Loundou, Anderson" sort="Loundou, Anderson" uniqKey="Loundou A" first="Anderson" last="Loundou">Anderson Loundou</name><name sortKey="Minaya Flores, Patricia" sort="Minaya Flores, Patricia" uniqKey="Minaya Flores P" first="Patricia" last="Minaya-Flores">Patricia Minaya-Flores</name><name sortKey="Pelletier, Jean" sort="Pelletier, Jean" uniqKey="Pelletier J" first="Jean" last="Pelletier">Jean Pelletier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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